Clinical Informatics Management System (CIMS)

 

Brief Description:

 

HPCIO has been developing a clinical care and research data management system to allow physicians and clinicians to conduct clinical trials and researches. The Clinical Informatics and Management System (CIMS) is a centralized clinical data management and analysis system that will assist NIH clinical investigators in managing protocols and patient and research data as well as in integrating disparate data sources for analysis. 

 

Clinical Informatics Management System (CIMS) overview schematic

Caption: Clinical Informatics Management System (CIMS) overview schematic


Schematic representation of multi-tiered architecture

Caption: Schematic representation of multi-tiered architecture


Collaborators

 

 

Major Accomplishments in FY 2007

 

In collaboration with Dr. Jordan Grafman, Senior Investigator and Chief of the Cognitive Neuroscience Section of NINDS , the CIMS project supported and completed the data migration of a phase III Vietnam Head Injury Study (VHIS) onto the Clinical Study Informatics System (CSIS) platform. VHIS is a longitudinal neuropsychological and medical study of Vietnam Veterans with penetrating head injury. This was a joint effort between the National Naval Medical Center (NNMC), NINDS and HPCIO. In this effort, HPCIO developed import tools for the migration of the post-injury data to be addressed for analysis related to cognitive neuroscience issues. The purpose of this research study is to determine the long-term consequences, if any, of head injury.

 

Anticipated Major Accomplishments in FY 2008

 

CSIS will continue on improving the dynamic query capability to include sub-queries and distributed queries that across multiple protocols for data discovery; creating an effective auditing mechanism for tracking accesses and changes made in the clinical database and protecting patient concerns and privacy; improving the form library re-usability such that forms can be modified and utilized across all protocols; creating a way to allow patient to fill out survey forms or other pre-admission forms over the web.

 

 

Metrics

 

Data migrated to CSIS in FY 2007 consisted of

 

Scientific Impact

 

Having imported the data from the National Naval Medical Center for the study of Vietnam Head Injury Study, CSIS provides a stable platform for researchers to examine targeted, cutting-edge cognitive neuroscience issues related to the role of head injury in the etiology of dementia, mechanisms of motor and cognitive recovery, and post-traumatic epilepsy. As a result of the study, clinicians and scientists can provide better treatment and prevention of physical disabilities and long-term consequences of cognitive, behavioral and social deficits.

 

Publications in FY 2007

 

“A Web-based Clinical Research Platform for Managing Multiple Clinical Research Studies”, H. Cheung, S.A. Wang, Y. Fann, B. Upender, S. Chintala, A. Frazin, W. Nie, C. Johnson, AMIA 2007 Annual Symposium

 


Other Publications

Huey Cheung, Yang Fann, Shaohua A. Wang, Barg Upender, Adam Frazin, Raj Lingam, Sarada Chintala, Frank Pecjak, Gladys Wang, Marc Kellogg, Robert L. Martino, and Calvin Johnson
"A Web-Based Protocol Tracking Management System For Clinical Research. “17th IEEE Symposium on Computer Based Medical Systems 24:25 June 2004 Bethesda, MD; 72-77 (2004)

 
Shaohua A Wang, Yang Fann, Huey Cheung, Frank Pecjak, Barg Upender, Adam Frazin, Raj Lingam, Sarada Chintala, Gladys Wang, Marc Kellogg, Robert L. Martino, and Calvin A. Johnson
"Performance of Using Oracle XMLDB in the Evaluation of CDISC ODM for a Clinical Study Informatics System." Proceedings 17th IEEE Symposium on Computer-Based Medical Systems 24:25 June 2004 Bethesda, MD; 594-599 (2004)

 
Cheung H, Wang A, Fann Y, Upender B, Chinatala S, Frazin A, Nie W, Martino R L, Johnson C, “A Web-Based Clinical Research Platform for Managing Multiple Clinical Research Studies.” Poster. NIH Research Festival 2006.